Although sex-change operations are not specifically mentioned in Scripture, human sexuality is spelled out clearly, starting in Genesis: “So God created people in his own image; God patterned them after himself; male and female he created them. God blessed them and told them, multiply and fill the earth and subdue it” (Genesis 1:27-28a). Genesis 1:31 tells us that His creation was excellent in every way. To say that gender does not matter is to disagree with God’s design for creation and His proclamation that it was very good.
God is also very clear about appropriate sexual behavior. Sex is to be had and enjoyed in a monogamous marriage relationship between a man and a woman (1 Corinthians 7:2; Hebrews 13:4). Homosexual behavior is wrong (Genesis 19:1-13; Leviticus 18:22; 20:13; Romans 1:26-27; 1 Corinthians 6:9). Cross-dressing is unacceptable (Deuteronomy 22:5). God talks about gender roles as well, such as male headship of the home and church (Ephesians 5:21-33). However, the Bible does not discuss culturally stereotypical gender roles. In fact, it gives a full view of personhood. While keeping the male-female distinction clear, the Bible provides multiple examples of men and women who are both nurturers and courageous leaders (such as David and the Proverbs 31 wife). Nowhere does the Bible imply that a person’s sex is negotiable or optional. The Bible affirms both males and females in their worth and their personhood. People’s gender matters, but we are not merely sexual beings (Galatians 3:23-29). It would seem, then, that sex-change procedures are not biblically acceptable. Source
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